Yes! This can be done. When I first setup I manually adjusted the Z-Offset thru LCD Menu, I only had end-stop switches then.
Though I used the line below to raise the Z axis up 10mm
#define Z_CLEARANCE_DEPLOY_PROBE 10
However if you adjust the Z-Offset to far the will cause the Z-End-Stop switch to be forced down (on My T-Slot frame it would force the Z_End-Stop switch to slide down)
This would make me realign the Z-End-Stop Switch and reset the Z-Offset values.
Though I used the line below to raise the Z axis up 10mm
#define Z_CLEARANCE_DEPLOY_PROBE 10
However if you adjust the Z-Offset to far the will cause the Z-End-Stop switch to be forced down (on My T-Slot frame it would force the Z_End-Stop switch to slide down)
This would make me realign the Z-End-Stop Switch and reset the Z-Offset values.