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Roxy
For sure you lose resolution. I don't know what happens with the Sli3r's. I know Slic3r moves the Z-Axis in partial steps when it is doing support material. But Marlin will work.
I think you are worrying too much about partial steps. Everybody uses the micro-stepping and it seems to work OK.
I don't worry, just that I don't like the idea of holding a position not corresponding to a full step. Although, now I modified my Prusa Zto run on just one motor.
I don't think resolution is an issue, no point having resolution in the micron range here. Just blowing at the printer, the frame will bent more than a micron :)
Thank for your time and for using the proper term, resolution and not accuracy :)